The Commodores got a solid pitching performance from Caleb Cotham (1-0) who pitched 7 1/3 innings and gave up four runs on seven hits and one walk while striking out nine.
"I think the biggest thing for me in the game was Caleb's ability to sit for long stretches while on offense and still go out and show plus command in the weather," said Vanderbilt head coach Tim Corbin. "I thought it was a very impressive start, he threw a lot of strikes and challenged the hitters and did a good job of controlling the game in spite of the weather conditions."
Russell Brewer came in to pitch a scoreless ninth and strike out two Cardinal hitters.
The Commodores got three runs in the bottom of the first inning to set the tone for the game. David Macias got hit by a pitch to lead off the game. Shortstop Ryan Flaherty was the next hitter to the plate and he homered to left center field. After a Dominic Del la Osa walk and Andrew Giobbi double, designated hitter Jonathan White flew out to left field scoring de la Osa.
Senior second baseman Alex Feinberg had a great day at the plate with three hits, including a three run homer in the bottom of the third inning, and five RBIs. He also scored two runs.
The Commodores also got home runs from Flaherty and right fielder de la Osa.
Freshman catcher Curt Casali had another great game going three for three with one RBI and three runs scored. He raised his average to .778 on the season.
Feinberg's home run ended Louisville starting pitcher James Belanger's (0-1) day after just 2 1/3 innings. Belanger allowed six runs on five hits and five walks.
The Commodores will be off on Wednesday before Illinois-Chicago comes to town for a four game series beginning Thursday afternoon.