The game featured big plays on special teams including a blocked field goal and a botched punt that gave Vandy possession deep in South Carolina territory.
Hawkins had 17 carries for 84 yards and a touchdown. His 13-yard fourth quarter jaunt gave Vanderbilt a 24-10 lead.
Chris Nickson, who rushed for a third quarter touchdown, also completed a 31-yard scoring pass to Brandon Barden in that quarter.
Vandy, 2-0, and on top of the SEC, will now have 9 days to prepare for the Rice Owls.
Check back for more on the game.